On the provinces of Coclé, Herrera and Los Santos the Catholic religion has been established for ages, which is clearly reflected by the community. Patron Saint celebrations and Religious Holidays are habitually commemorated with processions, especially during lent or in the week before Easter, when the passion and death of Jesus Christ is being represented. All over this area many churches can be found in front of a Plaza, a quintessential Spanish tradition that mixed with popular beliefs produced a singular religious mystic. Nata, in the Province of Coclé, is one of the oldest colonial cities and with the oldest church on the American Continent.

These provinces also contribute to the greatest expression of folkloric, art and crafts traditions of the country, which can above all be found back in the music, dance and handicrafts such as hats, ceramics, wood carvings, leather goods, baskets, vegetable fiber goods and the Panamanian National Dress the Pollera, which is handmade; mainly in the province of Los Santos. The Pollera with all it’s jewelry and ornaments makes a magnificent mixture that emphasizes the beauty of the Panamanian women.

The celebrations are generally accompanied by the typical dances of each region, cavalcades, religious expressions, local weddings, chariot’s parades and lots of typical food. The biggest and best know celebration is Carnival, a four-day fiesta that includes dancing, allegoric chariots, farce and euphoria. The most famous Carnival parties are held in Las Tablas and in Penonomé, the latter one celebrated on the waters of the River Las Mendozas, and they all present luxury costumes and fireworks. The last day of Carnival is commonly called "El Entierro de la Sardina" (the Sardine Burial), where a "Tuna" or "Comparsa" haunts the streets of the village wailing their lament for the finishing of the celebration.